Epithelium-poor type central odontogenic fibroma: An immunohistological study and review of the literature

Takashi Kimura, Seigo Ohba, Hitoshi Yoshimura, Naoki Katase, Yoshiaki Imamura, Takaaki Ueno, Hitoshi Nagatsuka, Kazuo Sano

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The object of this study was to determine the characteristics of central odontogenic fibroma (COF) in order to help achieve a correct diagnosis. Central odontogenic fibroma, which tends to be epithelium-poor, is an extremely rare type of odontogenic fibroma. The lack of data concerning COF, due to its low incidence, can make this entity difficult to diagnose. We herein report an epithelium-poor type of COF of the mandible, which we examined immunohistologically. We also provide a review of the previous English literature to expand the knowledge about this disease. Positive reactions for vimentin and negative reactions for desmin andα-smooth muscle actin (α-SMA) in COFs were common findings in the previous reports. We also noted similar immunohistological findings. Our data (vimentin positive,α-SMA and desmin negative) should contribute to correctly diagnosing epithelium-poor type COF.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalJournal of Hard Tissue Biology
Issue number2
Publication statusPublished - 2013


  • Central odontogenic fibroma
  • Epithelium-poor type
  • Mandible

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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