Essential cys-pro-cys motif of caenorhabditis elegans copper transport atpase

Takao Yoshimizu, Hiroshi Omote, Tokumitsu Wakabayashi, Yoshihiro Sambongi, Masamitsu Futai

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast Δccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast Δccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.

Original languageEnglish
Pages (from-to)1258-1260
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - Jan 1 1998
Externally publishedYes


  • Caenorhabditis elegans
  • Copper ATPase
  • Cysteine residue
  • Menkes and Wilson diseases
  • Yeast CCC2 gene

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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