TY - JOUR
T1 - Establishment and characterization of a mantle cell lymphoma cell line
AU - Jeon, H. O.Jong
AU - Kim, Chul Woo
AU - Yoshino, Tadashi
AU - Akagi, Tadaatsu
PY - 1998
Y1 - 1998
N2 - A mantle cell lymphoma (MCL) cell line (JeKo-1) was established from peripheral blood mononuclear cells of a patient with a large cell variant of MCL showing leukaemic conversion. JeKo-1 cells were Epstein-Barr virus negative and showed a B-cell phenotype with IgM+, IgD+, CD3-, CD5+, CD10-, CD19+, CD20+ and CD23-; they overexpressed cyclin D1, Bcl-2, c- Myc and Rb proteins. Bcl-1/J(H) gene rearrangement was confirmed by polymerase chain reaction, although karyotypic analysis showed 40/41 chromosomes devoid of apparent t(11;14)(q13;q32) translocation. JeKo-1 cells were highly tumourigenic in SCID mice.
AB - A mantle cell lymphoma (MCL) cell line (JeKo-1) was established from peripheral blood mononuclear cells of a patient with a large cell variant of MCL showing leukaemic conversion. JeKo-1 cells were Epstein-Barr virus negative and showed a B-cell phenotype with IgM+, IgD+, CD3-, CD5+, CD10-, CD19+, CD20+ and CD23-; they overexpressed cyclin D1, Bcl-2, c- Myc and Rb proteins. Bcl-1/J(H) gene rearrangement was confirmed by polymerase chain reaction, although karyotypic analysis showed 40/41 chromosomes devoid of apparent t(11;14)(q13;q32) translocation. JeKo-1 cells were highly tumourigenic in SCID mice.
KW - CD5
KW - Cell line
KW - Large cell variant
KW - Mantle cell lymphoma
KW - PRAD1/cyclin D1
UR - http://www.scopus.com/inward/record.url?scp=7344236837&partnerID=8YFLogxK
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U2 - 10.1046/j.1365-2141.1998.00911.x
DO - 10.1046/j.1365-2141.1998.00911.x
M3 - Article
C2 - 9753063
AN - SCOPUS:7344236837
SN - 0007-1048
VL - 102
SP - 1323
EP - 1326
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 5
ER -