Esterastin: A potent inhibitor of lysosomal acid lipase

Tsuneo Imanaka, Yoshinori Moriyama, Gnobor G. Ecsedi, Takaaki Aoyagi, Kimiko Amanuma-muto, Shoji Ohkuma, Tatsuya Takano

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The effect of a fungal metabolite, esterastin, on lysosomal acid lipase purified from rabbit liver was studied. Esterastin inhibited the enzyme activity very strongly (IC50, about 80 nM). The inhibition of acid lipase by esterastin was competitive with respect to the substrate and the inhibition constant for esterastin was 90 nM. Esterastin was less inhibitory to other lipolytic enzymes, such as pancreatic lipase and carboxylesterase. Thus esterastin is a potent new inhibitor of lysosomal acid lipase.

Original languageEnglish
Pages (from-to)1017-1020
Number of pages4
JournalJournal of biochemistry
Issue number3
Publication statusPublished - Jul 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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