Evaluation of Fast Diffusion Kurtosis Imaging Using New Software Designed for Widespread Clinical Use

Masahiro Kuroda, Kohei Konishi, Kohei Sugimoto, Yuuki Yoshimura, Kentaro Hamada, Abdullah Khasawneh, Majd Barham, Nouha Tekiki, Irfan Sugianto, Babatunde O. Bamgbose, Hinata Ishizaka, Yudai Shimizu, Yuki Nakamitsu, Wlla E. Al-Hammad, Ryo Kamizaki, Akira Kurozumi, Toshi Matsushita, Seiichiro Ohno, Susumu Kanazawa, Junichi Asaumi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalActa medica Okayama
Issue number3
Publication statusPublished - 2022


  • Excel
  • Fast diffusion kurtosis imaging
  • Imagej
  • Mean kurtosis
  • Restricted diffusion

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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