Evaluation of liver function parameters by Tc-99m-GSA using multivariate analysis: A study of 47 clinical cases

Yasunori Suzuki, Yoshihiro Kohno, Yoshihiro Takeda, Yoshio Hiraki

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6 Citations (Scopus)


To investigate the correlation between nuclear medicine parameters determined by technetium-99m-DTPA-galactosyl-human serum albumin (Tc-99m-GSA) and liver function tests, canonical correlation analysis was performed. Tc-99m-GSA studies were performed on 47 patients with hepatocellular carcinoma (HCC) who had undergone transcatheter arterial embolization (TAE). The nuclear medicine parameters LU15, HH15 and LHL15, which are results of nuclear imaging tests, were chosen in combination with the following liver function tests: the serum bilirubin level (T.Bil), the serum albumin level (Alb), serum cholinesterase activity (Ch-E), the clearance rate of indocyanine green (KICG), the hepaplastin test (HPT) and the prothrombin time (PT). The canonical correlation coefficient was 0.7345 and the upper tail probability was 0.00167. A significant correlation was observed between the two sets of variables. The high structural coefficients of Ch-E, KICG and HPT indicated a close relationship with the nuclear medicine parameters, supporting the notion that these nuclear medicine parameters are useful for the estimation of liver damage. The structural coefficients of the nuclear medicine parameters were also high, with LU15 being a parameter as useful as both HH15 and LHL15. T.Bil may evaluate a liver function that is not measured by nuclear imaging techniques, so we should take T.Bil results into account before considering TAE.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalActa medica Okayama
Issue number5
Publication statusPublished - Dec 1 1999


  • Hepatocellular carcinoma
  • Multivariate analysis
  • Technetium-99m-DTPA-galactosyl-human serum albumin
  • Transcatheter arterial embolization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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