TY - JOUR
T1 - Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts
T2 - Schistosoma japonicum and Clonorchis sinensis
AU - Ishii, Akira
AU - Matsuoka, Hiroyuki
AU - Aji, Toshiki
AU - Hayatsu, Hikoya
AU - Wataya, Yusuke
AU - Arimoto, Sakae
AU - Tokuda, Harukuni
PY - 1989/10
Y1 - 1989/10
N2 - In relation to the observed association of carcinogenesis with parasitic infections, the mutagenicity of extracts of Schistosoma japonicum and Clonorchis sinensis was examined. In the bacterial mutagenicity tests using the Ames Salmonella typhimurium strains TA98, TA100, TA97 and TA102, and Escherichia coli WP2 and WP2 uvrA pKM101 Schistosoma soluble egg antigen and a homogenate of adult Schistosoma worms showed no positive responses either in the presence or in the absence of S9 mix. Likewise, adult worm extracts of Clonorchis showed no mutagenicity. The Schistosoma soluble egg antigen showed a weak but significant activity for the induction of Epstein-Barr virus expression in viral genome-carrying human lymphoblastoid cells in culture. This phenomenon suggests that the soluble egg antigen possesses tumor-promoting activity.
AB - In relation to the observed association of carcinogenesis with parasitic infections, the mutagenicity of extracts of Schistosoma japonicum and Clonorchis sinensis was examined. In the bacterial mutagenicity tests using the Ames Salmonella typhimurium strains TA98, TA100, TA97 and TA102, and Escherichia coli WP2 and WP2 uvrA pKM101 Schistosoma soluble egg antigen and a homogenate of adult Schistosoma worms showed no positive responses either in the presence or in the absence of S9 mix. Likewise, adult worm extracts of Clonorchis showed no mutagenicity. The Schistosoma soluble egg antigen showed a weak but significant activity for the induction of Epstein-Barr virus expression in viral genome-carrying human lymphoblastoid cells in culture. This phenomenon suggests that the soluble egg antigen possesses tumor-promoting activity.
KW - Clonorchis
KW - Mutagenicity
KW - Parasite
KW - Schistosoma
KW - Tumor-promoting activity
UR - http://www.scopus.com/inward/record.url?scp=0024462699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024462699&partnerID=8YFLogxK
U2 - 10.1016/0165-1218(89)90160-2
DO - 10.1016/0165-1218(89)90160-2
M3 - Article
C2 - 2552310
AN - SCOPUS:0024462699
SN - 0165-1218
VL - 224
SP - 229
EP - 233
JO - Mutation Research/Genetic Toxicology
JF - Mutation Research/Genetic Toxicology
IS - 2
ER -