TY - JOUR
T1 - Ewing's sarcoma of the femur. Prognosis in 69 patients treated by the CESS group
AU - Ozaki, Toshifumi
AU - Hillmann, Axel
AU - Hoffmann, Christiane
AU - Rübe, Christian
AU - Dockhorn-Dworniczak, Barbara
AU - Blasius, Sebastian
AU - Dunst, Jürgen
AU - Treuner, Jörn
AU - Jürgens, Herbert
AU - Winkelmann, Winfried
N1 - Funding Information:
The authors thank Mrs. S. Jabar for the statistical analysis and her help in preparing the manuscript. Funds were re- ceived in total or partial support of the research or clinical study presented in this article. The funding sources were the “Deutsche Krebshilfe” (grant # M43/92/Jii2) and EC BIOMED 1’ (grant # BMHl -CT92-1341).
PY - 1997
Y1 - 1997
N2 - We reviewed the treatment outcome of 69 patient's with Ewing's sarcoma of the femur. The patients received chemotherapy according to the CESS 81 (n 14), CESS 86 (n 43), and CESS 91P (n 12) protocols. The 10-year relapse-free survival rates were 36%, 65%, and 65% (p = 0.01). 68 patients received local treatment. The primary tumor was treated by surgery without radiotherapy in 28 patients; 1 developed a local recurrence and 7 metastases. 10 patients received radiotherapy alone; 4 developed metastases and 4 local recurrences and metastases. 30 cases had a combination of surgery and radiotherapy; 7 developed metastases and 1 a local recurrence and metastasis. The survival of patients after radiotherapy alone was worse than that of patients after surgery with/without radiotherapy (p = 0.005). Pathological fractures (n 16) did not influence the prognosis.
AB - We reviewed the treatment outcome of 69 patient's with Ewing's sarcoma of the femur. The patients received chemotherapy according to the CESS 81 (n 14), CESS 86 (n 43), and CESS 91P (n 12) protocols. The 10-year relapse-free survival rates were 36%, 65%, and 65% (p = 0.01). 68 patients received local treatment. The primary tumor was treated by surgery without radiotherapy in 28 patients; 1 developed a local recurrence and 7 metastases. 10 patients received radiotherapy alone; 4 developed metastases and 4 local recurrences and metastases. 30 cases had a combination of surgery and radiotherapy; 7 developed metastases and 1 a local recurrence and metastasis. The survival of patients after radiotherapy alone was worse than that of patients after surgery with/without radiotherapy (p = 0.005). Pathological fractures (n 16) did not influence the prognosis.
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U2 - 10.3109/17453679709003970
DO - 10.3109/17453679709003970
M3 - Article
C2 - 9057563
AN - SCOPUS:8044247185
SN - 0001-6470
VL - 68
SP - 20
EP - 24
JO - Acta Orthopaedica Scandinavica
JF - Acta Orthopaedica Scandinavica
IS - 1
ER -