Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis

Shun Kitaba; Shigeki Inui; Ichiro Katayama; Yoshinari Matsumoto; Yumi Matsumura; Yoshiki Miyachi; Akiko Kishioka; Fukumi Furukawa; Yasuo Kubota; Gen Nakanishi; Keiji Iwatsuki; Sakae Kaneko; Eishin Morita; Kunio Izu; Yoshiki Tokura; Shuji Fukagawa; Masutaka Furue; Motoi Takenaka; Shinichi Sato; Kazumoto Katagiri

Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis

Shun Kitaba, Shigeki Inui, Ichiro Katayama, Yoshinari Matsumoto, Yumi Matsumura, Yoshiki Miyachi, Akiko Kishioka, Fukumi Furukawa, Yasuo Kubota, Gen Nakanishi, Keiji Iwatsuki, Sakae Kaneko, Eishin Morita, Kunio Izu, Yoshiki Tokura, Shuji Fukagawa, Masutaka Furue, Motoi Takenaka, Shinichi Sato, Kazumoto Katagiri

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups; (1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups. Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group. Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.

Original language	English
Pages (from-to)	8-14
Number of pages	7
Journal	Skin Research
Volume	6
Issue number	SUPPL. 8
Publication status	Published - Mar 2007

Keywords

Atopic dermatitis
Immunoglobulin E
Suplatast tosilate

ASJC Scopus subject areas

Dermatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Kitaba, S., Inui, S., Katayama, I., Matsumoto, Y., Matsumura, Y., Miyachi, Y., Kishioka, A., Furukawa, F., Kubota, Y., Nakanishi, G., Iwatsuki, K., Kaneko, S., Morita, E., Izu, K., Tokura, Y., Fukagawa, S., Furue, M., Takenaka, M., Sato, S., & Katagiri, K. (2007). Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis. Skin Research, 6(SUPPL. 8), 8-14.

Kitaba, S, Inui, S, Katayama, I, Matsumoto, Y, Matsumura, Y, Miyachi, Y, Kishioka, A, Furukawa, F, Kubota, Y, Nakanishi, G, Iwatsuki, K, Kaneko, S, Morita, E, Izu, K, Tokura, Y, Fukagawa, S, Furue, M, Takenaka, M, Sato, S & Katagiri, K 2007, 'Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis', Skin Research, vol. 6, no. SUPPL. 8, pp. 8-14.

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title = "Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis",

abstract = "We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups; (1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups. Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group. Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.",

keywords = "Atopic dermatitis, Immunoglobulin E, Suplatast tosilate",

author = "Shun Kitaba and Shigeki Inui and Ichiro Katayama and Yoshinari Matsumoto and Yumi Matsumura and Yoshiki Miyachi and Akiko Kishioka and Fukumi Furukawa and Yasuo Kubota and Gen Nakanishi and Keiji Iwatsuki and Sakae Kaneko and Eishin Morita and Kunio Izu and Yoshiki Tokura and Shuji Fukagawa and Masutaka Furue and Motoi Takenaka and Shinichi Sato and Kazumoto Katagiri",

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language = "English",

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T1 - Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis

AU - Kitaba, Shun

AU - Inui, Shigeki

AU - Katayama, Ichiro

AU - Matsumoto, Yoshinari

AU - Matsumura, Yumi

AU - Miyachi, Yoshiki

AU - Kishioka, Akiko

AU - Furukawa, Fukumi

AU - Kubota, Yasuo

AU - Nakanishi, Gen

AU - Iwatsuki, Keiji

AU - Kaneko, Sakae

AU - Morita, Eishin

AU - Izu, Kunio

AU - Tokura, Yoshiki

AU - Fukagawa, Shuji

AU - Furue, Masutaka

AU - Takenaka, Motoi

AU - Sato, Shinichi

AU - Katagiri, Kazumoto

PY - 2007/3

Y1 - 2007/3

N2 - We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups; (1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups. Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group. Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.

AB - We investigated the effects of oral Suplatast tosilate(IPD), the selective Th2 cytokine suppressor, on adult atopic dermatitis(AD). We divided the patients into two groups; (1)IPD+topical ointment (IPD group) and (2) antiallergic drug+topical ointment or topical ointment alone (control groups), and evaluated skin symptoms, serum immunoglobulin E level, LDH level, and the number of eosinophils and basophils. Although there were no significant improvement of laboratory data, skin symptoms improved in both groups. Especially in high value of immunoglobulin E and basophils patients, the IPD group showed significant improvement of skin symptoms compared with the control group. Therefore, we suggest that IPD may be more effective to the patients with high value of immunoglobulin E and basophils.

KW - Atopic dermatitis

KW - Immunoglobulin E

KW - Suplatast tosilate

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M3 - Article

AN - SCOPUS:34249034683

SN - 0018-1390

VL - 6

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JO - Skin Research

JF - Skin Research

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ER -

Examination of an inhibitory effect on the immunoglobulin E production by Th2 cytokine inhibitor on atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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