TY - JOUR
T1 - Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
AU - Muramatsu, Hideki
AU - Takahashi, Yoshiyuki
AU - Sakaguchi, Hirotoshi
AU - Shimada, Akira
AU - Nishio, Nobuhiro
AU - Hama, Asahito
AU - Doisaki, Sayoko
AU - Yagasaki, Hiroshi
AU - Matsumoto, Kimikazu
AU - Kato, Koji
AU - Kojima, Seiji
PY - 2011/2
Y1 - 2011/2
N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes from 1984 to 2008. Twelve patients were given oral IM. At 36 months after initiation of IM therapy, the complete cytogenetic response rate was 90.9%, and the major molecular response rate was 36.4%. Sixteen children received allogeneic HSCT without administration of IM. The stage of disease at transplantation was: first chronic phase (n = 10), second chronic phase (n = 2), accelerated phase (n = 2), and blastic crisis (n = 2). The progression rate was significantly lower in patients treated with IM than in those treated without IM (0 vs. 28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT.
AB - Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes from 1984 to 2008. Twelve patients were given oral IM. At 36 months after initiation of IM therapy, the complete cytogenetic response rate was 90.9%, and the major molecular response rate was 36.4%. Sixteen children received allogeneic HSCT without administration of IM. The stage of disease at transplantation was: first chronic phase (n = 10), second chronic phase (n = 2), accelerated phase (n = 2), and blastic crisis (n = 2). The progression rate was significantly lower in patients treated with IM than in those treated without IM (0 vs. 28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT.
KW - Chronic myeloid leukemia
KW - Imatinib mesylate
KW - Stem cell transplantation
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U2 - 10.1007/s12185-010-0764-9
DO - 10.1007/s12185-010-0764-9
M3 - Article
C2 - 21234820
AN - SCOPUS:79952251630
SN - 0925-5710
VL - 93
SP - 186
EP - 191
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 2
ER -