Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia

Tetsuhiko Toyoshima; Shinichi Yamagami; Bushra Y. Ahmed; Li Jin; Osamu Miyamoto; Toshifumi Itano; Masaaki Tokuda; Hideki Matsui; Osamu Hatase

Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia

Tetsuhiko Toyoshima, Shinichi Yamagami, Bushra Y. Ahmed, Li Jin, Osamu Miyamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Calbindin-D28K (calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.

Original language	English
Pages (from-to)	2087-2091
Number of pages	5
Journal	NeuroReport
Volume	7
Issue number	13
Publication status	Published - Nov 9 1996

Keywords

Calbindin-D28K
Hippocampus
Immunocytochemistry
Reactive astrocytes
Transient ischaemia

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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title = "Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia",

abstract = "Calbindin-D28K (calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.",

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AU - Toyoshima, Tetsuhiko

AU - Yamagami, Shinichi

AU - Ahmed, Bushra Y.

AU - Jin, Li

AU - Miyamoto, Osamu

AU - Itano, Toshifumi

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Hatase, Osamu

PY - 1996/11/9

Y1 - 1996/11/9

N2 - Calbindin-D28K (calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.

AB - Calbindin-D28K (calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.

KW - Calbindin-D28K

KW - Hippocampus

KW - Immunocytochemistry

KW - Reactive astrocytes

KW - Transient ischaemia

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Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia

Abstract

Keywords

ASJC Scopus subject areas

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