Expression of Collagen IV a1 to a6 Chains in Basement Membranes of Odontogenic Tumors

Hitoshi Nagatsuka, Eiki Fujii, Ryo Tamamura, Naoki Katase, Noriyuki Nagai, Chong Huat Siar, Yasushi Morimoto

Research output: Contribution to journalArticlepeer-review


Type IV collagen, the major component of basement membrane (BM), demonstrates a stage- and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of odontogenic neoplasms, immunohistochemistry using six anti- a (IV) chain-specific monoclonal antibodies was performed. Expression of a 1(IV)/ a 2(IV) and a 5(IV)/ a 6(IV) chains was stronger in the desmoplastic than in ordinary ameloblastomas. The adenomatoid odontogenic tumor distinctly expressed these chains in BM of cribriform areas and hyaline materials (which was also a 4(IV)-positive. These five chains also stained BM and tumor cells of ameloblastic fibroma. Present results suggest that collagen IV composition and distribution in the basement membranes of odontogenic neoplasms plays a key role in tumor growth and progression.

Original languageEnglish
Pages (from-to)130-131
Number of pages2
JournalJournal of Hard Tissue Biology
Issue number2
Publication statusPublished - Jan 2005


  • Ameloblastoma
  • Basement membrane
  • Type IV collagen

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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