Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma

Tadashi Yoshino; Shigeo Nakamura; Junji Suzumiya; Nozomi Niitsu; Koichi Ohshima; Junjiro Tsuchiyama; Katsuji Shinagawa; Mitsune Tanimoto; Yoshito Sadahira; Mine Harada; Masahiro Kikuchi; Tadaatsu Akagi

doi:10.1046/j.1365-2141.2002.03607.x

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma

Tadashi Yoshino, Shigeo Nakamura, Junji Suzumiya, Nozomi Niitsu, Koichi Ohshima, Junjiro Tsuchiyama, Katsuji Shinagawa, Mitsune Tanimoto, Yoshito Sadahira, Mine Harada, Masahiro Kikuchi, Tadaatsu Akagi

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA⁺ group (n = 29) had a much worse prognosis than the CLA^- group (n = 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.

Original language	English
Pages (from-to)	482-487
Number of pages	6
Journal	British Journal of Haematology
Volume	118
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03607.x
Publication status	Published - 2002

Keywords

Adhesion molecule
Cutaneous lymphocyte antigen
NK lymphoma
Nasal-type lymphoma
Prognostic factor

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.2002.03607.x

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Yoshino, T., Nakamura, S., Suzumiya, J., Niitsu, N., Ohshima, K., Tsuchiyama, J., Shinagawa, K., Tanimoto, M., Sadahira, Y., Harada, M., Kikuchi, M., & Akagi, T. (2002). Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma. British Journal of Haematology, 118(2), 482-487. https://doi.org/10.1046/j.1365-2141.2002.03607.x

Yoshino, T, Nakamura, S, Suzumiya, J, Niitsu, N, Ohshima, K, Tsuchiyama, J, Shinagawa, K, Tanimoto, M, Sadahira, Y, Harada, M, Kikuchi, M & Akagi, T 2002, 'Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma', British Journal of Haematology, vol. 118, no. 2, pp. 482-487. https://doi.org/10.1046/j.1365-2141.2002.03607.x

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abstract = "Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n = 29) had a much worse prognosis than the CLA- group (n = 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.",

keywords = "Adhesion molecule, Cutaneous lymphocyte antigen, NK lymphoma, Nasal-type lymphoma, Prognostic factor",

author = "Tadashi Yoshino and Shigeo Nakamura and Junji Suzumiya and Nozomi Niitsu and Koichi Ohshima and Junjiro Tsuchiyama and Katsuji Shinagawa and Mitsune Tanimoto and Yoshito Sadahira and Mine Harada and Masahiro Kikuchi and Tadaatsu Akagi",

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doi = "10.1046/j.1365-2141.2002.03607.x",

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AU - Yoshino, Tadashi

AU - Nakamura, Shigeo

AU - Suzumiya, Junji

AU - Niitsu, Nozomi

AU - Ohshima, Koichi

AU - Tsuchiyama, Junjiro

AU - Shinagawa, Katsuji

AU - Tanimoto, Mitsune

AU - Sadahira, Yoshito

AU - Harada, Mine

AU - Kikuchi, Masahiro

AU - Akagi, Tadaatsu

PY - 2002

Y1 - 2002

N2 - Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n = 29) had a much worse prognosis than the CLA- group (n = 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.

AB - Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n = 29) had a much worse prognosis than the CLA- group (n = 23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.

KW - Adhesion molecule

KW - Cutaneous lymphocyte antigen

KW - NK lymphoma

KW - Nasal-type lymphoma

KW - Prognostic factor

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ER -

Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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