TY - JOUR
T1 - Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse
AU - Kurose, Hitomi
AU - Bito, Takaaki
AU - Adachi, Taro
AU - Shimizu, Miyuki
AU - Noji, Sumihare
AU - Ohuchi, Hideyo
N1 - Funding Information:
We thank Hiroto Hirano for technical assistance. The PAX6 antibody developed by Dr Kawakami was obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by The University of Iowa, Department of Biological Sciences, Iowa City, IA 52242. This study was partly supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by Tanabe Medical Frontier Conference (TMFC).
PY - 2004/10
Y1 - 2004/10
N2 - The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19 -orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis.
AB - The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19 -orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis.
KW - Chicken
KW - Cranial placodes
KW - Embryogenesis
KW - Eye development
KW - FGF15
KW - FGF19
KW - Fibroblast growth factor
KW - Lens
KW - Mouse
KW - Retina
KW - Retinal horizontal cell
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U2 - 10.1016/j.modgep.2004.04.005
DO - 10.1016/j.modgep.2004.04.005
M3 - Article
C2 - 15465490
AN - SCOPUS:4744339897
SN - 1567-133X
VL - 4
SP - 687
EP - 693
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 6
ER -