Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

Hajime Isomoto; Mikio Oka; Yoshitsugu Yano; Yusei Kanazawa; Hiroshi Soda; Ryusuke Terada; Toru Yasutake; Toshiyuki Nakayama; Saburo Shikuwa; Fuminao Takeshima; Heiichiro Udono; Ikuo Murata; Kenzo Ohtsuka; Shigeru Kohno

doi:10.1016/S0304-3835(03)00305-7

Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

Hajime Isomoto, Mikio Oka, Yoshitsugu Yano, Yusei Kanazawa, Hiroshi Soda, Ryusuke Terada, Toru Yasutake, Toshiyuki Nakayama, Saburo Shikuwa, Fuminao Takeshima, Heiichiro Udono, Ikuo Murata, Kenzo Ohtsuka, Shigeru Kohno

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.

Original language	English
Pages (from-to)	219-228
Number of pages	10
Journal	Cancer Letters
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00305-7
Publication status	Published - Aug 2003
Externally published	Yes

Keywords

Gastric cancer
Heat shock protein 40
Heat shock protein 70
Immunoblot
Immunohistochemistry

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0304-3835(03)00305-7

Cite this

@article{0bc07fe875104c2d9726357dfa6a2bee,

title = "Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer",

abstract = "Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.",

keywords = "Gastric cancer, Heat shock protein 40, Heat shock protein 70, Immunoblot, Immunohistochemistry",

author = "Hajime Isomoto and Mikio Oka and Yoshitsugu Yano and Yusei Kanazawa and Hiroshi Soda and Ryusuke Terada and Toru Yasutake and Toshiyuki Nakayama and Saburo Shikuwa and Fuminao Takeshima and Heiichiro Udono and Ikuo Murata and Kenzo Ohtsuka and Shigeru Kohno",

year = "2003",

month = aug,

doi = "10.1016/S0304-3835(03)00305-7",

language = "English",

volume = "198",

pages = "219--228",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

AU - Isomoto, Hajime

AU - Oka, Mikio

AU - Yano, Yoshitsugu

AU - Kanazawa, Yusei

AU - Soda, Hiroshi

AU - Terada, Ryusuke

AU - Yasutake, Toru

AU - Nakayama, Toshiyuki

AU - Shikuwa, Saburo

AU - Takeshima, Fuminao

AU - Udono, Heiichiro

AU - Murata, Ikuo

AU - Ohtsuka, Kenzo

AU - Kohno, Shigeru

PY - 2003/8

Y1 - 2003/8

N2 - Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.

AB - Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.

KW - Gastric cancer

KW - Heat shock protein 40

KW - Heat shock protein 70

KW - Immunoblot

KW - Immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=17744416112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17744416112&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(03)00305-7

DO - 10.1016/S0304-3835(03)00305-7

M3 - Article

C2 - 12957361

AN - SCOPUS:17744416112

SN - 0304-3835

VL - 198

SP - 219

EP - 228

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this