Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats

Ikuko Miyazaki; Chiharu Sogawa; Masato Asanuma; Youichirou Higashi; Ken Ichi Tanaka; Tohru Nakanishi; Norio Ogawa

doi:10.1016/S0304-3940(00)01488-9

Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats

Ikuko Miyazaki, Chiharu Sogawa, Masato Asanuma, Youichirou Higashi, Ken Ichi Tanaka, Tohru Nakanishi, Norio Ogawa

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Neuroscience Letters
Volume	293
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(00)01488-9
Publication status	Published - Oct 20 2000

Keywords

Growth inhibitory factor
Hemi-parkinsonism
Levodopa
Metallothionein-III
Oxidative stress
Parkinson's disease

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01488-9

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title = "Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats",

abstract = "In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Growth inhibitory factor, Hemi-parkinsonism, Levodopa, Metallothionein-III, Oxidative stress, Parkinson's disease",

author = "Ikuko Miyazaki and Chiharu Sogawa and Masato Asanuma and Youichirou Higashi and Tanaka, {Ken Ichi} and Tohru Nakanishi and Norio Ogawa",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research on Priority Area and for Scientific Research (C: 11670629) from the Japanese Ministry of Education, Science, Sports and Culture, and by Grants-in-Aid for Comprehensive Research on Aging and Health, and for Research on Specific Diseases from the Japanese Ministry of Health and Welfare.",

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AU - Miyazaki, Ikuko

AU - Sogawa, Chiharu

AU - Asanuma, Masato

AU - Higashi, Youichirou

AU - Tanaka, Ken Ichi

AU - Nakanishi, Tohru

AU - Ogawa, Norio

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research on Priority Area and for Scientific Research (C: 11670629) from the Japanese Ministry of Education, Science, Sports and Culture, and by Grants-in-Aid for Comprehensive Research on Aging and Health, and for Research on Specific Diseases from the Japanese Ministry of Health and Welfare.

PY - 2000/10/20

Y1 - 2000/10/20

N2 - In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Growth inhibitory factor

KW - Hemi-parkinsonism

KW - Levodopa

KW - Metallothionein-III

KW - Oxidative stress

KW - Parkinson's disease

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Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats

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