Expression of Notch in a case of osteosarcoma of the maxilla

Toshiyuki Kawakami, C. H. Siar, K. H. Ng, T. Shimizu, N. Okafuji, S. Kurihara, H. Hasegawa, H. Tsujigiwa, H. Nagatsuka, N. Nagai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


In this immunohistochemical examination, the expression of Notch1 peptide was detected in neo-plastic cells in a case of osteosarcoma of the maxilla of a 31 -year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation of acquisition of cytological characteristics in neoplastic cells of osteosarcoma.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalEuropean journal of medical research
Issue number11
Publication statusPublished - 2004


  • Cyto-differentiation
  • Cytological characteristics
  • Immunohistochemistry
  • Morphogenesis
  • Morphogenesis regulation factor
  • Notch1 peptide
  • Osteosarcoma

ASJC Scopus subject areas

  • Medicine(all)


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