TY - JOUR
T1 - Expression of Notch1 and Hes5 in the developing olfactory epithelium
AU - Orita, Yorihisa
AU - Nagatsuka, Hitoshi
AU - Tsujigiwa, Hidetsugu
AU - Yoshinobu, Junko
AU - Maeda, Yukihide
AU - Kakiuchi, Masashi
AU - Orita, Saeko
AU - Takeuchi, Ayako
AU - Takeda, Yasushi
AU - Fukushima, Kunihiro
AU - Nagai, Noriyuki
AU - Nishizaki, Kazunori
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Conclusion. Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE. Materials and methods. The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined. Results. As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.
AB - Conclusion. Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE. Materials and methods. The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined. Results. As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.
KW - Development
KW - In situ hybridization
KW - Notch signal
KW - Olfactory epithelium
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U2 - 10.1080/00016480500437419
DO - 10.1080/00016480500437419
M3 - Article
C2 - 16698699
AN - SCOPUS:33646499917
SN - 0001-6489
VL - 126
SP - 498
EP - 502
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 5
ER -