Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis

Gang Du, Ken Kataoka, Masakiyo Sakaguchi, Fernando Abarzua, Swe Swe Than, Hiroyuki Sonegawa, Teruhiko Makino, Tadamichi Shimizu, Nam Ho Huh

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalExperimental Dermatology
Issue number3
Publication statusPublished - Mar 2011


  • Hyperproliferative epidermis
  • REIC/Dkk-3
  • Skin cancer
  • TPA
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


Dive into the research topics of 'Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis'. Together they form a unique fingerprint.

Cite this