Expression of sclerostin in the regenerating scales of goldfish and its increase under microgravity during space flight

Tatsuki Yamamoto, Mika Ikegame, Jun Hirayama, Kei Ichiro Kitamura, Yoshiaki Tabuchi, Yukihiro Furusawa, Toshio Sekiguchi, Masato Endo, Hiroyuki Mishima, Azusa Seki, Sachiko Yano, Hajime Matsubara, Atsuhiko Hattori, Nobuo Suzuki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Osteocytes, osteoblasts (bone-forming cells), and osteoclasts (bone-resorbing cells) are the primary types of cells that regulate bone metabolism in mammals. Sclerostin produced in bone cells acti-vates osteoclasts, inhibiting bone formation; excess production of sclerostin, therefore, leads to the loss of bone mass. Fish scales have been reported to have morphological and functional similari-ties to mammalian bones, making them a useful experimental system for analyzing vertebrate bone metabolism in vitro. However, whether fish scales contain cells producing sclerostin and/or osteocytes has not been determined. The current study demonstrated, for the first time, that scle-rostin-containing cells exist in goldfish scales. Analysis of the distribution and shape of scleros-tin-expressing cells provided evidence that osteoblasts produce sclerostin in goldfish scales. Furthermore, our results found that osteocyte-like cells exist in goldfish scales, which also produce sclerostin. Finally, we demonstrated that microgravity in outer space increased the level of scleros-tin in the scales of goldfish, a finding suggesting that the induction of sclerostin is the mechanism underlying the activation of osteoclasts under microgravity.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalBiomedical Research (Japan)
Issue number6
Publication statusPublished - 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Expression of sclerostin in the regenerating scales of goldfish and its increase under microgravity during space flight'. Together they form a unique fingerprint.

Cite this