TY - JOUR
T1 - Expression of the JNK2-α1 gene in the developing chick brain
AU - Ishikawa, Tetsuya
AU - Nakada-Moriya, Yoko
AU - Ando, Chiyo
AU - Tanda, Nobuya
AU - Nishida, Seikoh
AU - Minatogawa, Yosuke
AU - Nohnon, Tsutomu
N1 - Funding Information:
This work was supported in part by a grant from the Japanese Ministry of Education, Science and Culture, and by a research project grant from Kawasaki Medical School.
PY - 1997/5/19
Y1 - 1997/5/19
N2 - We have isolated chicken JNK2-α1 encoding a c-Jun N-terminal kinase, and examined the expression during embryogenesis. The kinase domain sequence is well conserved between chicken and mammals, but carboxy-terminal sequence of JNK is divergent from subtype 1 and 2, possibly derived from alternative splicing. The JNK2-α1 gene is preferentially expressed in the neuroepithelium of developing brain at stages 16-26, and transcripts are not detectable in the other region including spinal cord. These results suggest that JNK2-α1 is involved in development of the central nervous system as a mediator of stress-activated protein kinase pathway conferring competence to the external stimuli such as growth factors.
AB - We have isolated chicken JNK2-α1 encoding a c-Jun N-terminal kinase, and examined the expression during embryogenesis. The kinase domain sequence is well conserved between chicken and mammals, but carboxy-terminal sequence of JNK is divergent from subtype 1 and 2, possibly derived from alternative splicing. The JNK2-α1 gene is preferentially expressed in the neuroepithelium of developing brain at stages 16-26, and transcripts are not detectable in the other region including spinal cord. These results suggest that JNK2-α1 is involved in development of the central nervous system as a mediator of stress-activated protein kinase pathway conferring competence to the external stimuli such as growth factors.
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U2 - 10.1006/bbrc.1997.6140
DO - 10.1006/bbrc.1997.6140
M3 - Article
C2 - 9177299
AN - SCOPUS:0031578182
SN - 0006-291X
VL - 234
SP - 489
EP - 492
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -