Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma

Mitsuru Munemasa, Tadashi Yoshino, Keita Kobayashi, Takayoshi Miyake, Sumie Takase-Sakugawa, Tomohiko Mannami, Katsuji Shinagawa, Mitsune Tanimoto, Tadaatsu Akagi

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3 Citations (Scopus)


Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 cases of thyroid MALT lymphoma using paraffinembedded, formalin-fixed tissue specimens. In all cases of thyroid MALT lymphoma, human Tg was detected immunohistochemically in the follicular epithelial cells and follicular dendritic cells (FDCs). These FDCs were positive by double immunostaining for anti-human Tg rabbit polyclonal antibody (Ab) and for CD35. Results showed that the Tg, a thyroid autoantigen, had immunostained the germinal center of the thyroid MALT lymphoma. The Tg was present in the FDCs, as revealed by the staining pattern of the germinal center;this fact was confirmed by double immunostaining of anti-human Tg mouse monoclonal Ab and anti-CD35 mouse monoclonal Ab. The results of our study suggest that Tg is an autoantigen that is recognized by thyroid MALT lymphoma cells.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalActa medica Okayama
Issue number2
Publication statusPublished - May 2009


  • Follicular dendritic cells
  • Mucosa-associated lymphoid tissue lymphoma
  • Thyroglobulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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