TY - JOUR
T1 - Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes
AU - Noji, Sumihare
AU - Matsuo, Toshihiko
AU - Koyama, Eiki
AU - Yamaai, Tomoichiro
AU - Nohno, Tsutomu
AU - Matsuo, Nobuhiko
AU - Taniguchi, Shigehiko
N1 - Funding Information:
Drs. Makoto Iwane, Koichi Igarashi and Atsushi Biotechnology Laboratories of Takeda Chemical LTD. for aFGF and bFGF cDNAs. Supported in part by The Ministry of Education, Science and Culture of
PY - 1990/4/16
Y1 - 1990/4/16
N2 - Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells.
AB - Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells.
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U2 - 10.1016/0006-291X(90)91714-4
DO - 10.1016/0006-291X(90)91714-4
M3 - Article
C2 - 2328010
AN - SCOPUS:0025344519
SN - 0006-291X
VL - 168
SP - 343
EP - 349
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -