Extracorporeal membrane oxygenation following norwood stage 1 procedures at a single institution

Shinya Ugaki, Shingo Kasahara, Yasuhiro Kotani, Mahito Nakakura, Takuma Douguchi, Hideshi Itoh, Sadahiko Arai, Shunji Sano

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Extracorporeal membrane oxygenation (ECMO) is an important circulatory assist for children with refractory cardiopulmonary dysfunction, but its role and indications after a stage 1 Norwood procedure are controversial. We assessed outcomes and risk factors in patients who underwent a Norwood palliation and ECMO at our institution. We retrospectively reviewed all patients who underwent a Norwood procedure and were supported with ECMO between January 1998 and January 2010. Of the 91 children who underwent a Norwood procedure during the study period, there were 15 postoperative runs of ECMO in 12 patients. The diagnoses of the patients included five with hypoplastic left heart syndrome, five with a hypoplastic left heart syndrome variant, and two with critical aortic stenosis. A total of four patients underwent bilateral pulmonary artery banding, and two patients underwent aortic valvuloplasty before the stage 1 Norwood procedure. The mean age of the patients was 28 ± 30 days, and mean body weight was 2.6 ± 0.5 kg at the induction of ECMO. The indications for ECMO were low cardiac output in six children, circulatory collapse needing cardiopulmonary resuscitation in six children, and hypoxemia in three children. Five of the 12 patients were successfully weaned from ECMO. The significant risk factors for the inability to be weaned from ECMO were a history of circulatory collapse requiring cardiopulmonary resuscitation, and the induction of ECMO in the intensive care unit. Induction of ECMO may be considered earlier when hemodynamics are unstable in impaired patients following a stage 1 Norwood procedure to avoid circulatory collapse.

Original languageEnglish
Pages (from-to)898-903
Number of pages6
JournalArtificial Organs
Issue number11
Publication statusPublished - Nov 2010


  • Cardiac
  • Extracorporeal membrane oxygenation
  • Hypoplastic heart syndrome
  • Infant
  • Norwood procedure

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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