Extraction of ethyl ester of polyunsaturated fatty acids by utilizing slug flow prepared by microreactor

Yu Seike, Eiji Kamio, Tsutomu Ono, Hidekazu Yoshizawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


By utilizing a microreactor, extraction of ethyl ester of docosahexaenoic acid (DHA-Et) and eicosapentaenoic acid (EPA-Et) from an organic solution into an aqueous silver nitrate solution has been investigated. Slug flow preapared by using a T-shape microreactor was used to extract DHA-Et and EPA-Et. Utilizing slug flow created large specific interfacial area between aqueous and organic phases, and ultra fast extraction has been achieved. Extraction of both DHA-Et and EPA-Et took less than 20 s to reach equilibrium. In all of the experiments, the amount of DHA-Et or EPA-Et extracted was the same to that expected from the batch experiment. These facts indicate that the microreactor system can realize an ultra-fast examination system of extraction equilibrium. In addition, by maintaining the temperature quite low, a drastic improvement of extraction ratio is exhibited under a low silver nitrate concentration condition. That is, it can easily cut down silver nitrate by utilizing a microreactor. This is preferable for the practical operation.

Original languageEnglish
Pages (from-to)1076-1084
Number of pages9
Issue number12
Publication statusPublished - Dec 20 2007


  • Liquid-liquid extraction
  • Microreactor
  • Polyunsaturated fatty acid
  • Silver ion
  • Slug flow

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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