Familial interstitial nephritis with progressive renal failure.

H. Zhang, J. Wada, K. Nanba, M. Kunitomi, K. Hida, Y. Nagake, K. Shikata, H. Makino

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We describe a 53-year-old woman with chronic interstitial nephritis and asymptomatic impairment of renal function. Seven members of her family were suffering from renal failure and underwent hemodialysis. At the time of their hospital admissions, they had shown evidence of end-stage renal failure at 40 to 50 years of age. Lack of proteinuria, hematuria, hypertension, hyperuricemia, hearing loss, and visual impairment were present before the deterioration of the renal function. Renal biopsy of the presented case indicated chronic interstitial nephritis without glomerular basement membrane abnormalities. Progressive decline of renal function and the inheritance pattern of autosomal dominance in this family suggested the diagnosis of familial interstitial nephritis.

Original languageEnglish
Pages (from-to)E25
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Issue number4
Publication statusPublished - Oct 2000

ASJC Scopus subject areas

  • Nephrology


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