Fatal glioblastoma after Gamma Knife radiosurgery for arteriovenous malformation in a child

Koichi Yoshida, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Keisuke Onoda, Isao Date

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


We describe a fatal case of glioblastoma multiforme that was induced by Gamma Knife radiosurgery (GKS; Elekta AB, Stockholm, Sweden) for an arteriovenous malformation (AVM). A 4-year-old girl presented with repeated convulsions. Imaging studies revealed an AVM located in the right thalamus. One year after initial symptoms, GKS was performed to obliterate the nidus. The maximum and marginal radiation doses were 32 and 16 Gy, respectively. Seventy months after GKS, the patient represented with severe headache. MRI showed a poorly demarcated tumor with heterogeneous gadolinium enhancement in the right thalamus and adjacent to the white matter of the temporal lobe. After a generalised convulsion, the patient deteriorated into a deep coma. CT scans showed severe brain swelling with intratumoral hemorrhage. An emergency craniotomy was performed, and the hematoma was removed. During this surgery, a tumor mass, which was found adjacent to the hematoma, was resected. Microscopic examination revealed glioblastoma multiforme. Despite intensive treatment, the patient died 1 month after surgery. A GKS-induced secondary tumor is a rare but serious complication. It is important to be aware of the adverse effects of GKS, including secondary neoplasms, before its clinical application, especially in young patients.

Original languageEnglish
Pages (from-to)1453-1455
Number of pages3
JournalJournal of Clinical Neuroscience
Issue number8
Publication statusPublished - Aug 2014


  • Arteriovenous malformations
  • Gamma Knife radiosurgery
  • Glioblastoma multiforme
  • Radiation-induced neoplasms

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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