TY - JOUR
T1 - Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support
AU - Ohuchi, Katsuhiro
AU - Hoshi, Hideo
AU - Iwasaki, Yasuhiko
AU - Ishihara, Kazuhiko
AU - Yoshikawa, Masaharu
AU - Ugaki, Shinya
AU - Ishino, Kozo
AU - Osaki, Satoru
AU - Kotani, Yasuhiro
AU - Sano, Shunji
AU - Takatani, Setsuo
PY - 2007/5
Y1 - 2007/5
N2 - In this study, the performances of the TinyPump (priming volume 5 mL) system including the pediatric cannulae (Stöckert Pediatric Arterial Cannulae 2.6, 3.0, and 4.0 mm, Stöckert Instruments GmbH, Munich, Germany; Polystan 20-Fr Venous Catheter, MAQUET GmbH, Rastatt, Germany) and an oxygenator (Terumo Capiox RX05 Baby-RX, Terumo Cardiovascular Systems Co., Tokyo, Japan) were studied in vitro followed with preliminary ex vivo studies in 20-kg piglets. In vitro results revealed that the TinyPump system met the requirements for pump speed, pump flow, and pressure drop as extracorporeal circulatory support during open heart surgery and extracorporeal membrane oxygenation (ECMO) in pediatric patients. In 2-h ex vivo studies using 20-kg piglets where the blood contacting surface of the TinyPump was coated with a biocompatible phospholipid polymer, the plasma-free hemoglobin levels remained less than 5.0 mg/dL and no thrombus formation was observed inside the pump. The TinyPump system including the oxygenator and connecting circuits resulted in an overall priming volume of 68 mL, the smallest ever reported. The TinyPump can be a safe option for pediatric circulatory support during open heart surgery and ECMO without requiring blood transfusion.
AB - In this study, the performances of the TinyPump (priming volume 5 mL) system including the pediatric cannulae (Stöckert Pediatric Arterial Cannulae 2.6, 3.0, and 4.0 mm, Stöckert Instruments GmbH, Munich, Germany; Polystan 20-Fr Venous Catheter, MAQUET GmbH, Rastatt, Germany) and an oxygenator (Terumo Capiox RX05 Baby-RX, Terumo Cardiovascular Systems Co., Tokyo, Japan) were studied in vitro followed with preliminary ex vivo studies in 20-kg piglets. In vitro results revealed that the TinyPump system met the requirements for pump speed, pump flow, and pressure drop as extracorporeal circulatory support during open heart surgery and extracorporeal membrane oxygenation (ECMO) in pediatric patients. In 2-h ex vivo studies using 20-kg piglets where the blood contacting surface of the TinyPump was coated with a biocompatible phospholipid polymer, the plasma-free hemoglobin levels remained less than 5.0 mg/dL and no thrombus formation was observed inside the pump. The TinyPump system including the oxygenator and connecting circuits resulted in an overall priming volume of 68 mL, the smallest ever reported. The TinyPump can be a safe option for pediatric circulatory support during open heart surgery and ECMO without requiring blood transfusion.
KW - Cardiopulmonary bypass
KW - Centrifugal blood pump
KW - Extracorporeal membrane oxygenation
KW - Pediatric circulatory support
KW - Ventricular assist device
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U2 - 10.1111/j.1525-1594.2007.00401.x
DO - 10.1111/j.1525-1594.2007.00401.x
M3 - Article
C2 - 17470213
AN - SCOPUS:34247612585
SN - 0160-564X
VL - 31
SP - 408
EP - 412
JO - Artificial Organs
JF - Artificial Organs
IS - 5
ER -