TY - JOUR
T1 - Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease
AU - Ohta, Yasuyuki
AU - Nomura, Emi
AU - Hatanaka, Noriko
AU - Osakada, Yosuke
AU - Matsumoto, Namiko
AU - Sasaki, Ryo
AU - Tsunoda, Keiichiro
AU - Takemoto, Mami
AU - Tadokoro, Koh
AU - Hishikawa, Nozomi
AU - Wakutani, Yosuke
AU - Yamashita, Toru
AU - Sato, Kota
AU - Omote, Yosio
AU - Abe, Koji
N1 - Funding Information:
We thank all the participants for their participation in the present study. This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419619 , (C) 15K0931607 , 17H0419619 , and 17K1082709 , and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from the Japan Agency for Medical Research and Development , Japan 7211700176 , 7211700180 , and 7211700095 .
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Associations of sarcopenia and physical frailty in cognitive and affective (depression, apathy, and behavioral and psychological symptoms of dementia) functions of mild cognitive impairment (MCI) and Alzheimer's disease (AD) were not fully evaluated previously, especially not for gender differences. 165 AD, 84 MCI, and 48 control participants (175 female, 122 male) were evaluated for cognitive, affective, activities of daily living (ADL), and physical functions associated with sarcopenia and physical frailty. In both sexes, cognitive and affective functions, ADL, and physical functions worsened in MCI and AD compared to control subjects. Physical dysfunctions, especially slow gait speed (3 m up and go test), were significantly associated with cognitive, affective, and ADL declines in participants (control subjects, MCI, and AD) of each gender, which were especially noticeable in females. The present study may be the first to suggest significant associations of sarcopenia and physical frailty with cognitive and affective functions of MCI and AD, especially in females.
AB - Associations of sarcopenia and physical frailty in cognitive and affective (depression, apathy, and behavioral and psychological symptoms of dementia) functions of mild cognitive impairment (MCI) and Alzheimer's disease (AD) were not fully evaluated previously, especially not for gender differences. 165 AD, 84 MCI, and 48 control participants (175 female, 122 male) were evaluated for cognitive, affective, activities of daily living (ADL), and physical functions associated with sarcopenia and physical frailty. In both sexes, cognitive and affective functions, ADL, and physical functions worsened in MCI and AD compared to control subjects. Physical dysfunctions, especially slow gait speed (3 m up and go test), were significantly associated with cognitive, affective, and ADL declines in participants (control subjects, MCI, and AD) of each gender, which were especially noticeable in females. The present study may be the first to suggest significant associations of sarcopenia and physical frailty with cognitive and affective functions of MCI and AD, especially in females.
KW - Alzheimer's disease
KW - Gender difference
KW - MCI
KW - Physical frailty
KW - Sarcopenia
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U2 - 10.1016/j.jocn.2019.08.062
DO - 10.1016/j.jocn.2019.08.062
M3 - Article
C2 - 31444048
AN - SCOPUS:85070919729
SN - 0967-5868
VL - 70
SP - 96
EP - 101
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -