TY - JOUR
T1 - FGF-10 is a growth factor for preadipocytes in white adipose tissue
AU - Yamasaki, Masahiro
AU - Emoto, Hisayo
AU - Konishi, Morichika
AU - Mikami, Tadahisa
AU - Ohuchi, Hideyo
AU - Nakao, Kazuwa
AU - Itoh, Nobuyuki
N1 - Funding Information:
This work was supported in part by the Takeda Science Foundation, the Yamanouchi Foundation on Metabolic Disorders, the Yamada Science Foundation, and Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.
PY - 1999/4/29
Y1 - 1999/4/29
N2 - FGF-10 is a mesenchymal factor affecting epithelial cells during pattern formation. However, the expression and physiological role of FGF-10 in adults remains to be elucidated. We examined the expression of FGF-10 mRNA in a variety of adult rat tissues, and found to be most abundant in white adipose tissue. In white adipose tissue, FGF-10 mRNA was expressed in preadipocytes but not in mature adipocytes. The expression in white adipose tissue during postnatal development was also examined. The expression level was low at postnatal day 10 (P10). However, FGF-10 mRNA was abundantly detected later on (P28 and P48) when white adipose tissue growth was stimulated. We also examined the activity of recombinant FGF-10 for primary rat preadipocytes. FGF-10 showed significant mitogenic activity for primary preadipocytes, but did not affect the differentiation of preadipocytes. The expression profile of FGF-10 mRNA and the activity of FGF-10 reported here indicate that FGF-10, a unique secreted factor produced in white adipose tissue, acts as a growth factor for preadipocytes in white adipose tissues.
AB - FGF-10 is a mesenchymal factor affecting epithelial cells during pattern formation. However, the expression and physiological role of FGF-10 in adults remains to be elucidated. We examined the expression of FGF-10 mRNA in a variety of adult rat tissues, and found to be most abundant in white adipose tissue. In white adipose tissue, FGF-10 mRNA was expressed in preadipocytes but not in mature adipocytes. The expression in white adipose tissue during postnatal development was also examined. The expression level was low at postnatal day 10 (P10). However, FGF-10 mRNA was abundantly detected later on (P28 and P48) when white adipose tissue growth was stimulated. We also examined the activity of recombinant FGF-10 for primary rat preadipocytes. FGF-10 showed significant mitogenic activity for primary preadipocytes, but did not affect the differentiation of preadipocytes. The expression profile of FGF-10 mRNA and the activity of FGF-10 reported here indicate that FGF-10, a unique secreted factor produced in white adipose tissue, acts as a growth factor for preadipocytes in white adipose tissues.
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U2 - 10.1006/bbrc.1999.0594
DO - 10.1006/bbrc.1999.0594
M3 - Article
C2 - 10222243
AN - SCOPUS:0033614487
SN - 0006-291X
VL - 258
SP - 109
EP - 112
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -