Fibrillar ultrastructure of the glomerular basement membrane of the rat kidney as revealed by digestive treatment.

A. Ichiyasu, M. Takaoka, H. Makino, K. Takahashi, Z. Ota

Research output: Contribution to journalArticlepeer-review

Abstract

Rat kidney glomerular basement membrane (GBM) was isolated and digested with alpha-amylase and elastase. Electron microscopy revealed a meshwork structure composed of fibrils 3 nm in width. They appeared to be type IV collagen fibrils. We succeeded in clarifying a significant ultrastructural aspect of the GBM which had been unclear until now. The findings are consistent with our previously proposed GBM molecular sieve theory.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalActa medica Okayama
Volume41
Issue number4
Publication statusPublished - Aug 1987

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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