Fibroblast growth factor 10 is required for proper development of the mouse whiskers

Hideyo Ohuchi, Hirotaka Tao, Kazuyo Ohata, Nobuyuki Itoh, Shigeaki Kato, Sumihare Noji, Katsuhiko Ono

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Mar 14 2003
Externally publishedYes


  • Fibroblast growth factor 10
  • Hair development
  • Knockout
  • Mouse
  • Patched
  • Sinus hair
  • Sonic hedgehog
  • Vibrissa
  • Whisker

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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