Fibroblast growth factor 10 is required for proper development of the mouse whiskers

Hideyo Ohuchi; Hirotaka Tao; Kazuyo Ohata; Nobuyuki Itoh; Shigeaki Kato; Sumihare Noji; Katsuhiko Ono

doi:10.1016/S0006-291X(03)00183-9

Fibroblast growth factor 10 is required for proper development of the mouse whiskers

Hideyo Ohuchi, Hirotaka Tao, Kazuyo Ohata, Nobuyuki Itoh, Shigeaki Kato, Sumihare Noji, Katsuhiko Ono

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.

Original language	English
Pages (from-to)	562-567
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	302
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(03)00183-9
Publication status	Published - Mar 14 2003
Externally published	Yes

Keywords

Fibroblast growth factor 10
Hair development
Knockout
Mouse
Patched
Sinus hair
Sonic hedgehog
Vibrissa
Whisker

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(03)00183-9

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title = "Fibroblast growth factor 10 is required for proper development of the mouse whiskers",

abstract = "Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.",

keywords = "Fibroblast growth factor 10, Hair development, Knockout, Mouse, Patched, Sinus hair, Sonic hedgehog, Vibrissa, Whisker",

author = "Hideyo Ohuchi and Hirotaka Tao and Kazuyo Ohata and Nobuyuki Itoh and Shigeaki Kato and Sumihare Noji and Katsuhiko Ono",

note = "Funding Information: We thank Dr. Jun Motoyama for mouse Ptch and Ptch2 probes. This study was partly supported by Grants in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by Tanabe Medical Frontier Conference (TMFC).",

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doi = "10.1016/S0006-291X(03)00183-9",

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AU - Ohuchi, Hideyo

AU - Tao, Hirotaka

AU - Ohata, Kazuyo

AU - Itoh, Nobuyuki

AU - Kato, Shigeaki

AU - Noji, Sumihare

AU - Ono, Katsuhiko

N1 - Funding Information: We thank Dr. Jun Motoyama for mouse Ptch and Ptch2 probes. This study was partly supported by Grants in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by Tanabe Medical Frontier Conference (TMFC).

PY - 2003/3/14

Y1 - 2003/3/14

N2 - Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.

AB - Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.

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KW - Hair development

KW - Knockout

KW - Mouse

KW - Patched

KW - Sinus hair

KW - Sonic hedgehog

KW - Vibrissa

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Fibroblast growth factor 10 is required for proper development of the mouse whiskers

Abstract

Keywords

ASJC Scopus subject areas

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