TY - JOUR
T1 - Fingolimod increases parvalbumin-positive neurons in adult mice
AU - Ueno, Hiroshi
AU - Takahashi, Yu
AU - Murakami, Shinji
AU - Wani, Kenta
AU - Matsumoto, Yosuke
AU - Okamoto, Motoi
AU - Ishihara, Takeshi
N1 - Funding Information:
We thank R. Kuyama and R. Fujita for technical assistance and the Kawasaki Medical School Central Research Institute for providing the instruments used in this study. We would also like to thank Editage (www.editage.jp) for their English language editing services. All authors had full access to all study data and take full responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: H.U. M.O. and T.I.; Acquisition of data: H.U. and Y.T.; Analysis and interpretation of data: H.U. and Y.T.; Drafting of the manuscript: H.U. and M.O.; Critical revision of the manuscript for important intellectual content: S.M. K.W. Y.T. Y.M. and T.I.; Statistical analysis: H.U. and Y.T.; Study supervision: M.O. and T.I. The authors declare they have no competing financial interests.
Publisher Copyright:
© 2022 The Authors
PY - 2022/12
Y1 - 2022/12
N2 - In recent years, it has been shown that central nervous system agents, such as antidepressants and antiepileptic drugs, reopen a critical period in mature animals. Fingolimod, which is used for the treatment of multiple sclerosis, also restores neuroplasticity. In this study, we investigated the effects of parvalbumin (PV)-positive neurons and perineuronal nets (PNN) on fingolimod administration with respect to neuroplasticity. Fingolimod was chronically administered intraperitoneally to mature mice. PV-positive neurons and PNN in the hippocampus, prefrontal cortex, and somatosensory cortex were analyzed. An increase in PV-positive neurons was observed in the hippocampus, prefrontal cortex, and somatosensory cortex of the fingolimod-treated mice. An increase in Wisteria floribunda agglutinin-positive PNN was confirmed in mice treated with fingolimod in the somatosensory cortex only. Fingolimod increased the density of PV-positive neurons in the brains of mature mice. The results indicate that fingolimod may change the critical period in mature animals.
AB - In recent years, it has been shown that central nervous system agents, such as antidepressants and antiepileptic drugs, reopen a critical period in mature animals. Fingolimod, which is used for the treatment of multiple sclerosis, also restores neuroplasticity. In this study, we investigated the effects of parvalbumin (PV)-positive neurons and perineuronal nets (PNN) on fingolimod administration with respect to neuroplasticity. Fingolimod was chronically administered intraperitoneally to mature mice. PV-positive neurons and PNN in the hippocampus, prefrontal cortex, and somatosensory cortex were analyzed. An increase in PV-positive neurons was observed in the hippocampus, prefrontal cortex, and somatosensory cortex of the fingolimod-treated mice. An increase in Wisteria floribunda agglutinin-positive PNN was confirmed in mice treated with fingolimod in the somatosensory cortex only. Fingolimod increased the density of PV-positive neurons in the brains of mature mice. The results indicate that fingolimod may change the critical period in mature animals.
KW - Fingolimod
KW - Hippocampus
KW - Parvalbumin
KW - Perineuronal nets
KW - Prefrontal cortex
KW - Somatosensory cortex
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U2 - 10.1016/j.ibneur.2022.06.005
DO - 10.1016/j.ibneur.2022.06.005
M3 - Article
AN - SCOPUS:85134320482
SN - 2667-2421
VL - 13
SP - 96
EP - 106
JO - IBRO Neuroscience Reports
JF - IBRO Neuroscience Reports
ER -