First Total Synthesis of Reassigned Echinosulfonic Acid D

Takumi Abe, Ren Nakajima, Toshiki Yamashiro, Daisuke Sawada

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Echinosulfonic acid D, a sponge metabolite whose structure was recently reassigned, was synthesized for the first time. The key step is the double indolization of dimethylbarbituric acid using the umpolung indole reagent, followed by a hydrolysis/decarboxylation/esterification sequence.

Original languageEnglish
Pages (from-to)2122-2125
Number of pages4
JournalJournal of Natural Products
Issue number8
Publication statusPublished - Aug 26 2022

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'First Total Synthesis of Reassigned Echinosulfonic Acid D'. Together they form a unique fingerprint.

Cite this