Five patients with painless thyroiditis simultaneously developed in a nursery school

T. Ogura, S. Hirakawa, S. Suzuki, Z. Ota, T. Togawa, I. Nogami

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Painless (silent) thyroiditis (PT) occurred simultaneously in 1 male and 4 females aged 21 to 52 years working at a nursery school. Clinical symptoms did not include goiter, or pain or tenderness of the neck in any of the patients but were characterized by edema of the lower legs as well as palpitation and loss of body weight as observed in subacute thyroiditis. General blood analysis showed that all patients were negative for C-reactive protein (CRP) and 3 had mild impairment of liver function. Examination of thyroid function suggested transient thyrotoxicosis accompanied by a marked reduction in radioactive iodine uptake (RAIU), but antithyroglobulin hemagglutination antibody (THGA) and antithyroid microsomal hemagglutination antibody (MCHA) were negative in all patients. Examination of various viral antibodies showed no significant changes in their titers. Thyrotoxicosis was transient and disappeared without treatment or by glucocorticoid administration. Our results suggested that PT observed in this study was caused by some environmental factor. The possibility of an unidentified virus as a factor cannot be ruled out.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalEndocrinologia Japonica
Issue number2
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • General Engineering


Dive into the research topics of 'Five patients with painless thyroiditis simultaneously developed in a nursery school'. Together they form a unique fingerprint.

Cite this