Flavan dimers with lipase inhibitory activity from Cassia nomame

Tsutomu Hatano, Akiko Yamashita, Toshitaka Hashimoto, Hideyuki Ito, Naoki Kubo, Masaaki Yoshiyama, Susumu Shimura, Yoshio Itoh, Takuo Okuda, Takashi Yoshida

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Five flavan dimers which showed lipase-inhibiting effects were isolated from fruits of Cassia nomame (Leguminosae). Structures of two new compounds among them were determined to be (2S)-3',4',7-trihydroxyflavan-(4β→8)- catechin and (2S)-3',4',7-trihydroxyflavan-(4α→8)-catechin. Four flavan dimers structurally related to these two compounds were also synthesized for spectral comparison. Among 10 flavan dimers tested for lipase-inhibitory activity, (2S)-3',4',7-trihydroxyflavan-(4α→8)-catechin showed the most potent inhibitory effect. A partially purified fraction composed of oligomeric flavans with M(n) 1020 also showed a noticeable inhibitory effect.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
Issue number5
Publication statusPublished - Nov 1 1997


  • Cassia nomame
  • Flavan dimer
  • Leguminosae
  • Lipase inhibitor
  • Oligomeric flavanoid
  • Tannin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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