Fluorescence enhancement by a SiO2-based monolithic waveguide structure for biomolecular detection

Ken Ichi Nomura, Thangavel Lakshmipriya, Nobuko Fukuda, Xiaomin Wang, Makoto Fujimaki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We have developed a fluorescence enhancement system for biomolecular detection using a monolithic waveguide sensing plate. The plate consists of a thermally grown amorphous SiO2 layer, a Si single-crystal layer, and bulk amorphous SiO2. Waveguide-mode excitation in this plate produces an enhanced electric field on the plate surface, and therefore, signals from analyte-labeling fluorescent dyes are enhanced. In the present paper, we elucidate the impact of the system from viewpoints of the electric field enhancement factor calculated numerically and the analysis of the limit of detection estimated from experimental results. Optimal layer thicknesses of the plates to achieve the highest sensitivity are also discussed. Further, an interesting phenomenon that accompanied the waveguide-mode excitation, namely, photoluminescence from the amorphous SiO2 layer itself, is also reported.

Original languageEnglish
Article number143103
JournalJournal of Applied Physics
Issue number14
Publication statusPublished - Apr 14 2013
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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