Four cases of desquamative esophagitis occurring after hematopoietic stem cell transplantation

Masaya Iwamuro; Daisuke Ennishi; Ken Ichi Matsuoka; Takehiro Tanaka; Shotaro Okanoue; Yuka Obayashi; Hiroyuki Sakae; Yoshiro Kawahara; Hiroyuki Okada

doi:10.2169/internalmedicine.4977-20

Four cases of desquamative esophagitis occurring after hematopoietic stem cell transplantation

Masaya Iwamuro, Daisuke Ennishi, Ken Ichi Matsuoka, Takehiro Tanaka, Shotaro Okanoue, Yuka Obayashi, Hiroyuki Sakae, Yoshiro Kawahara, Hiroyuki Okada

Research output: Contribution to journal › Article › peer-review

Abstract

We herein report four patients with desquamative esophagitis that developed one to nine days after peripheral blood stem cell transplantation (PBSCT). Three patients underwent allogeneic PBSCT for leukemia, and the other underwent autologous PBSCT for pineoblastoma. Esophagogastroduodenoscopy revealed mucosal sloughing and fresh blood in the esophagus. Fasting and intravenous proton pump inhibitor therapy in addition to blood transfusion improved the esophageal lesions within five to seven days in three patients. These cases indicate that desquamative esophagitis can occur in patients who receive hematopoietic stem cell transplantation. Although blood transfusions may be required, it can be resolved within seven days.

Original language	English
Pages (from-to)	3015-3022
Number of pages	8
Journal	Internal Medicine
Volume	59
Issue number	23
DOIs	https://doi.org/10.2169/internalmedicine.4977-20
Publication status	Published - Dec 1 2020

Keywords

Desquamative esophagitis
Esophagitis dissecans superficialis
Peripheral blood stem cell transplantation
Sloughing esophagitis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.4977-20

Cite this

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title = "Four cases of desquamative esophagitis occurring after hematopoietic stem cell transplantation",

abstract = "We herein report four patients with desquamative esophagitis that developed one to nine days after peripheral blood stem cell transplantation (PBSCT). Three patients underwent allogeneic PBSCT for leukemia, and the other underwent autologous PBSCT for pineoblastoma. Esophagogastroduodenoscopy revealed mucosal sloughing and fresh blood in the esophagus. Fasting and intravenous proton pump inhibitor therapy in addition to blood transfusion improved the esophageal lesions within five to seven days in three patients. These cases indicate that desquamative esophagitis can occur in patients who receive hematopoietic stem cell transplantation. Although blood transfusions may be required, it can be resolved within seven days.",

keywords = "Desquamative esophagitis, Esophagitis dissecans superficialis, Peripheral blood stem cell transplantation, Sloughing esophagitis",

author = "Masaya Iwamuro and Daisuke Ennishi and Matsuoka, {Ken Ichi} and Takehiro Tanaka and Shotaro Okanoue and Yuka Obayashi and Hiroyuki Sakae and Yoshiro Kawahara and Hiroyuki Okada",

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doi = "10.2169/internalmedicine.4977-20",

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AU - Iwamuro, Masaya

AU - Ennishi, Daisuke

AU - Matsuoka, Ken Ichi

AU - Tanaka, Takehiro

AU - Okanoue, Shotaro

AU - Obayashi, Yuka

AU - Sakae, Hiroyuki

AU - Kawahara, Yoshiro

AU - Okada, Hiroyuki

PY - 2020/12/1

Y1 - 2020/12/1

N2 - We herein report four patients with desquamative esophagitis that developed one to nine days after peripheral blood stem cell transplantation (PBSCT). Three patients underwent allogeneic PBSCT for leukemia, and the other underwent autologous PBSCT for pineoblastoma. Esophagogastroduodenoscopy revealed mucosal sloughing and fresh blood in the esophagus. Fasting and intravenous proton pump inhibitor therapy in addition to blood transfusion improved the esophageal lesions within five to seven days in three patients. These cases indicate that desquamative esophagitis can occur in patients who receive hematopoietic stem cell transplantation. Although blood transfusions may be required, it can be resolved within seven days.

AB - We herein report four patients with desquamative esophagitis that developed one to nine days after peripheral blood stem cell transplantation (PBSCT). Three patients underwent allogeneic PBSCT for leukemia, and the other underwent autologous PBSCT for pineoblastoma. Esophagogastroduodenoscopy revealed mucosal sloughing and fresh blood in the esophagus. Fasting and intravenous proton pump inhibitor therapy in addition to blood transfusion improved the esophageal lesions within five to seven days in three patients. These cases indicate that desquamative esophagitis can occur in patients who receive hematopoietic stem cell transplantation. Although blood transfusions may be required, it can be resolved within seven days.

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KW - Peripheral blood stem cell transplantation

KW - Sloughing esophagitis

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Four cases of desquamative esophagitis occurring after hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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