@article{545c02cc872c4da7a883cf33602aa3e7,
title = "Four-Step One-Pot Catalytic Asymmetric Synthesis of Polysubstituted Tricyclic Compounds: Lipase-Catalyzed Dynamic Kinetic Resolution Followed by an Intramolecular Diels-Alder Reaction",
abstract = "Starting from readily available tertiary alcohols, four different reactions (a 1,3-migration of a hydroxy group, kinetic resolution, racemization, and an intramolecular Diels-Alder reaction) took place under co-catalysis by lipase and oxovanadium compounds in a one-pot process to produce polysubstituted tricyclic carbon frameworks in high yields and with high enantioselectivities. The key to the success of this process was the discovery that a silyl group attached to the terminal carbon of the vinyl moiety completely controls the direction of hydroxy group migration.",
keywords = "Diels-Alder reaction, allylic alcohols, asymmetric synthesis, dynamic kinetic resolution, lipase, one-pot reaction",
author = "Izuru Tsuchimochi and Shuhei Hori and Yasuo Takeuchi and Masahiro Egi and Satoh, {Tomo O.} and Kyohei Kanomata and Takashi Ikawa and Shuji Akai",
note = "Funding Information: This work was financially supported by the JSPS KAKENHI [18HO4411 (Middle Molecular Strategy) and 18H02556] and the Platform Project for Supporting Drug Discovery and Life Science Research [Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from AMED under grant number JP20am0101084.JapaAngenMfcoyredRicaee aacnhDdevelopme(ntJP20am0101084JapaSnochPfeooermoiSocnifen(ce18H02556JapSaonchiPfeoetymroScoiofnence 18HO4411) Publisher Copyright: {\textcopyright} 2021 Georg Thieme Verlag. All rights reserved.",
year = "2021",
month = may,
day = "12",
doi = "10.1055/a-1344-8713",
language = "English",
volume = "32",
pages = "822--828",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "8",
}