Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma

Christina Bluemel; Ken Herrmann; Urs Müller-Richter; Constantin Lapa; Takahiro Higuchi; Vanessa Wild; Andreas K. Buck; Alexander Kübler; Christian Linz

doi:10.1002/hed.23596

Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma

Christina Bluemel, Ken Herrmann, Urs Müller-Richter, Constantin Lapa, Takahiro Higuchi, Vanessa Wild, Andreas K. Buck, Alexander Kübler, Christian Linz

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background In oral squamous cell carcinoma (OSCC), cervical lymph node status is the most important prognostic factor. Compared to elective neck dissection, reduced morbidity and better quality of life was demonstrated for sentinel lymph node biopsy, which is controversial because of the reduced detection rate of sentinel lymph nodes in close proximity to the injection site (also known as the shine-through phenomenon). Methods We report the case of a 44-year-old woman with a biopsy-proven early OSCC of the anterior floor of the mouth, who received SLNB guided with freehand single-photon emission CT (fhSPECT), a system for the 3D visualization of radioactivity in the body. Results One level III sentinel lymph node and 1 level I sentinel lymph node, in close proximity to the injection site, were detected and dissected. The level I sentinel lymph node contained a metastasis. Conclusion Using fhSPECT, the issue outlined was overcome, and the precise histopathological lymph node status (pN1; 1 of 49) was determined.

Original language	English
Pages (from-to)	E112-E116
Journal	Head and Neck
Volume	36
Issue number	11
DOIs	https://doi.org/10.1002/hed.23596
Publication status	Published - Nov 1 2014
Externally published	Yes

Keywords

freehand single-photon emission CT (fhSPECT)
head and neck cancer
neck dissection
sentinel lymph node biopsy
squamous cell carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.23596

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title = "Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma",

abstract = "Background In oral squamous cell carcinoma (OSCC), cervical lymph node status is the most important prognostic factor. Compared to elective neck dissection, reduced morbidity and better quality of life was demonstrated for sentinel lymph node biopsy, which is controversial because of the reduced detection rate of sentinel lymph nodes in close proximity to the injection site (also known as the shine-through phenomenon). Methods We report the case of a 44-year-old woman with a biopsy-proven early OSCC of the anterior floor of the mouth, who received SLNB guided with freehand single-photon emission CT (fhSPECT), a system for the 3D visualization of radioactivity in the body. Results One level III sentinel lymph node and 1 level I sentinel lymph node, in close proximity to the injection site, were detected and dissected. The level I sentinel lymph node contained a metastasis. Conclusion Using fhSPECT, the issue outlined was overcome, and the precise histopathological lymph node status (pN1; 1 of 49) was determined.",

keywords = "freehand single-photon emission CT (fhSPECT), head and neck cancer, neck dissection, sentinel lymph node biopsy, squamous cell carcinoma",

author = "Christina Bluemel and Ken Herrmann and Urs M{\"u}ller-Richter and Constantin Lapa and Takahiro Higuchi and Vanessa Wild and Buck, {Andreas K.} and Alexander K{\"u}bler and Christian Linz",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley Periodicals, Inc. Head Neck 36: E112-E116, 2014 {\textcopyright} 2014 Wiley Periodicals, Inc.",

year = "2014",

month = nov,

day = "1",

doi = "10.1002/hed.23596",

language = "English",

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journal = "Head and Neck",

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T1 - Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma

AU - Bluemel, Christina

AU - Herrmann, Ken

AU - Müller-Richter, Urs

AU - Lapa, Constantin

AU - Higuchi, Takahiro

AU - Wild, Vanessa

AU - Buck, Andreas K.

AU - Kübler, Alexander

AU - Linz, Christian

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Background In oral squamous cell carcinoma (OSCC), cervical lymph node status is the most important prognostic factor. Compared to elective neck dissection, reduced morbidity and better quality of life was demonstrated for sentinel lymph node biopsy, which is controversial because of the reduced detection rate of sentinel lymph nodes in close proximity to the injection site (also known as the shine-through phenomenon). Methods We report the case of a 44-year-old woman with a biopsy-proven early OSCC of the anterior floor of the mouth, who received SLNB guided with freehand single-photon emission CT (fhSPECT), a system for the 3D visualization of radioactivity in the body. Results One level III sentinel lymph node and 1 level I sentinel lymph node, in close proximity to the injection site, were detected and dissected. The level I sentinel lymph node contained a metastasis. Conclusion Using fhSPECT, the issue outlined was overcome, and the precise histopathological lymph node status (pN1; 1 of 49) was determined.

AB - Background In oral squamous cell carcinoma (OSCC), cervical lymph node status is the most important prognostic factor. Compared to elective neck dissection, reduced morbidity and better quality of life was demonstrated for sentinel lymph node biopsy, which is controversial because of the reduced detection rate of sentinel lymph nodes in close proximity to the injection site (also known as the shine-through phenomenon). Methods We report the case of a 44-year-old woman with a biopsy-proven early OSCC of the anterior floor of the mouth, who received SLNB guided with freehand single-photon emission CT (fhSPECT), a system for the 3D visualization of radioactivity in the body. Results One level III sentinel lymph node and 1 level I sentinel lymph node, in close proximity to the injection site, were detected and dissected. The level I sentinel lymph node contained a metastasis. Conclusion Using fhSPECT, the issue outlined was overcome, and the precise histopathological lymph node status (pN1; 1 of 49) was determined.

KW - freehand single-photon emission CT (fhSPECT)

KW - head and neck cancer

KW - neck dissection

KW - sentinel lymph node biopsy

KW - squamous cell carcinoma

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Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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