TY - JOUR
T1 - Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas
AU - Katase, Naoki
AU - Gunduz, Mehmet
AU - Beder, Levent Bekir
AU - Gunduz, Esra
AU - Sheikh Ali, Mahmoud Al
AU - Tamamura, Ryo
AU - Yaykasli, Kursat Oguz
AU - Yamanaka, Noboru
AU - Shimizu, Kenji
AU - Nagatsuka, Hitoshi
N1 - Funding Information:
This work was partially supported by grants-in-aid for scientific researches from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to H.N.), 20791337 (to R.T.)], Seed Innovation Research from Japan Science and Technology Agency (to M.G.), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to M.G.) and As-trazeneca Research Grant (to M.G.).
PY - 2010
Y1 - 2010
N2 - Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.
AB - Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.
KW - Biomarker
KW - Dickkopf (Dkk)-1
KW - Head and neck squamous cell carcinoma
KW - Loss of heterozygosity
KW - Metastasis
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U2 - 10.3109/07357900903095680
DO - 10.3109/07357900903095680
M3 - Article
C2 - 19995224
AN - SCOPUS:72449125627
SN - 0735-7907
VL - 28
SP - 103
EP - 110
JO - Cancer Investigation
JF - Cancer Investigation
IS - 1
ER -
