TY - JOUR
T1 - Functional Differentiation of Memory Retrieval Network in Macaque Posterior Parietal Cortex
AU - Miyamoto, Kentaro
AU - Osada, Takahiro
AU - Adachi, Yusuke
AU - Matsui, Teppei
AU - Kimura, Hiroko M.
AU - Miyashita, Yasushi
N1 - Funding Information:
This work was supported in part by MEXT/JSPS KAKENHI Grant Numbers 19002010 and 24220008 to Y.M., by CREST, Japan Science and Technology Agency to Y.M., by a grant from Takeda Science Foundation to Y.M., and by Japan Society for the Promotion of Science Research Fellowships for Young Scientists to K.M. (234682) and T.M. (201204982). One Japanese monkey used in this research was provided by NBRP “Japanese Monkeys” through the National BioResource Project of the MEXT. We thank Tomomi Watanabe for technical assistance and Seiki Konishi and Takamitsu Watanabe for helpful comments on the manuscript.
PY - 2013/2/20
Y1 - 2013/2/20
N2 - Human fMRI studies revealed involvement of the posterior parietal cortex (PPC) during memory retrieval. However, corresponding memory-related regions in macaque PPC have not been established. In this monkey fMRI study, comparisons of cortical activity during correct recognition of previously seen items and rejection of unseen items revealed two major PPC activation sites that were differentially characterized by a serial probe recognition paradigm: area PG/PGOp in inferior parietal lobule, along with the hippocampus, was more active for initial item retrieval, while area PEa/DIP in intraparietal sulcus was for the last item. Effective connectivity analyses revealed that connectivity from hippocampus to PG/PGOp, but not to PEa/DIP, increased during initial item retrieval. The two parietal areas with differential serial probe recognition profiles were embedded in two different subnetworks of the brain-wide retrieval-related regions. These functional dissociations in the macaque PPC imply the functional correspondence of retrieval-related PPC networks in macaques and humans
AB - Human fMRI studies revealed involvement of the posterior parietal cortex (PPC) during memory retrieval. However, corresponding memory-related regions in macaque PPC have not been established. In this monkey fMRI study, comparisons of cortical activity during correct recognition of previously seen items and rejection of unseen items revealed two major PPC activation sites that were differentially characterized by a serial probe recognition paradigm: area PG/PGOp in inferior parietal lobule, along with the hippocampus, was more active for initial item retrieval, while area PEa/DIP in intraparietal sulcus was for the last item. Effective connectivity analyses revealed that connectivity from hippocampus to PG/PGOp, but not to PEa/DIP, increased during initial item retrieval. The two parietal areas with differential serial probe recognition profiles were embedded in two different subnetworks of the brain-wide retrieval-related regions. These functional dissociations in the macaque PPC imply the functional correspondence of retrieval-related PPC networks in macaques and humans
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U2 - 10.1016/j.neuron.2012.12.019
DO - 10.1016/j.neuron.2012.12.019
M3 - Article
C2 - 23439129
AN - SCOPUS:84874244403
SN - 0896-6273
VL - 77
SP - 787
EP - 799
JO - Neuron
JF - Neuron
IS - 4
ER -