Functional evaluation of the ethanol extracts from rosmarinus officinalis l. (rosemary)

Naofumi Yamada, Tsutomu Yamasaki, Kana Yamawaki, Minami Nakagiri, Hideyuki Ito, Yoshimasa Nakamura, Tohru Nakanishi

Research output: Contribution to journalArticlepeer-review


Rosemary is used as an herb in cooking and aromatic oils, and has long been used as a medicinal herb because of its functional components. According to folklore, monks recommended a remedy of rosemary in alcohol (“Hungarian wa-ter”) to a Hungarian queen suffering from limb numbness, resulting in instant recovery and rejuvenation. This is why the queen married a 20-year-old king of Holland while in her seventies. In order to clarify the “rejuvenation” mechanisms of traditional Hungarian water, we examined the anti-oxidant activity, anti-glycation activity, inhibition of melanin production and suppression of tumor growth of ethanol extracts of rosemary in this study. It was found that the ethanol extract had high anti-oxidant activity, high anti-glycation activity, high inhibition of melanin production and high suppression of tumor cell growth.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalJournal of Hard Tissue Biology
Issue number3
Publication statusPublished - 2021


  • Anti-glycation activity
  • Anti-oxidant activity
  • Melanin production
  • Rosemary
  • Tumor cell growth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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