G72 gene is associated with susceptibility to methamphetamine psychosis

Tatsuya Kotaka, Hiroshi Ujike, Yuko Okahisa, Manabu Takaki, Kenji Nakata, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Methamphetamine psychosis is considered as one of the pharmacological models of schizophrenia, and a hyperdopaminergic one. However, many lines of experimental evidence indicate that glutamatergic signaling is also involved in development of methamphetamine psychosis. Several genes related to glutamate function, e.g. the DTNBP1, G72, and GRM3 genes, were shown to be associated with schizophrenia susceptibility. Recently, we found significant association of the DTNBP1 gene with methamphetamine psychosis. This finding prompted us to examine the G72 gene encoding the d-amino acid oxidase activator (DAOA), which metabolizes d-serine, an NMDA co-agonist, in methamphetamine psychosis. Six SNPs of the G72 gene, which previously showed significant association with schizophrenia, were analyzed in 209 patients with methamphetamine psychosis and 291 age- and sex-matched normal controls. One SNP of M22 (rs778293) showed a significant association with methamphetamine psychosis (genotype: p = 0.00016, allele: p = 0.0015). Two haplotypes G-A of M12 (rs3916965)-M15 (rs2391191) (p = 0.00024) and T-T of M23 (rs947267)-M24 (rs1421292) (p = 0.00085) also showed associations with methamphetamine psychosis. The present findings suggest that the G72 gene may contribute to a predisposition to not only schizophrenia but also to methamphetamine psychosis.

Original languageEnglish
Pages (from-to)1046-1049
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number6
Publication statusPublished - Aug 31 2009


  • Amphetamines
  • G30
  • Glutamate
  • Schizophrenia
  • Substance-induced psychosis

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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