TY - JOUR
T1 - Galanin Inhibits Noradrenaline‐Induced Accumulation of Cyclic AMP in the Rat Cerebral Cortex
AU - Nishibori, Masahiro
AU - Oishi, Ryozo
AU - Itoh, Yoshinori
AU - Saeki, Kiyomi
PY - 1988/12
Y1 - 1988/12
N2 - Abstract: The effect of galanin on poradrenaline (NA)‐induced accumulation of cyclic AMP was investigated in slices of rat cerebral cortex. NA (10−4M) increased cyclic AMP levels during a 20‐min observation period. Galanin (3 × 10−7M) significantly inhibited this response at all time points examined, although it did not change the basal levels of cyclic AMP. Galanin (10−3× 10−6M) inhibited the cyclic AMP response to NA (10−4M) in a dose‐dependent manner, with an IC50 of ∼5.6 × 10−5M and a maximum inhibition of 59%. These results suggest that galanin, devoid of any detectable effects by itself, modulates the cyclic AMP response to NA in the rat cerebral cortex.
AB - Abstract: The effect of galanin on poradrenaline (NA)‐induced accumulation of cyclic AMP was investigated in slices of rat cerebral cortex. NA (10−4M) increased cyclic AMP levels during a 20‐min observation period. Galanin (3 × 10−7M) significantly inhibited this response at all time points examined, although it did not change the basal levels of cyclic AMP. Galanin (10−3× 10−6M) inhibited the cyclic AMP response to NA (10−4M) in a dose‐dependent manner, with an IC50 of ∼5.6 × 10−5M and a maximum inhibition of 59%. These results suggest that galanin, devoid of any detectable effects by itself, modulates the cyclic AMP response to NA in the rat cerebral cortex.
KW - Cyclic AMP accumulation
KW - Galanin
KW - Noradrenaline
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U2 - 10.1111/j.1471-4159.1988.tb01185.x
DO - 10.1111/j.1471-4159.1988.tb01185.x
M3 - Article
C2 - 2460591
AN - SCOPUS:0024212649
SN - 0022-3042
VL - 51
SP - 1953
EP - 1955
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 6
ER -