TY - JOUR
T1 - Gastric mucosal protection and superoxide dismutase
AU - Ogino, Keiki
AU - Oka, Shinji
AU - Okazaki, Yukinori
AU - Takemoto, Tadayoshi
PY - 1988/12
Y1 - 1988/12
N2 - Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.
AB - Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.
KW - Aminotriazole
KW - Diethyldithiocarbamate
KW - Gastric ulcer
KW - Superoxide dismutase
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U2 - 10.1097/00004836-198812001-00019
DO - 10.1097/00004836-198812001-00019
M3 - Article
C2 - 2846684
AN - SCOPUS:0023682503
SN - 0192-0790
VL - 10
SP - S129-S132
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
ER -