Gastrin-Releasing Peptide

Research output: Chapter in Book/Report/Conference proceedingChapter


Gastrin-releasing peptide (GRP) was originally isolated from the porcine stomach, and was believed to be the mammalian counterpart of the amphibian peptide bombesin – itself originally isolated from the porcine stomach and subsequently in other vertebrates. A large body of research indicates that GRP is distributed widely in the central nervous system of mammals in addition to the gastrointestinal tract. In mammals, bombesin-like peptides act through a family of at least three G protein-coupled receptors (GPCRs), namely the GRP-preferring receptor (GRPR), the NMB-preferring receptor, and bombesin receptor subtype-3, which is considered an orphan receptor. To date, it has been reported that GRP plays significant roles in many physiological processes, including food intake, circadian rhythms, male sexual behavior, and fear memory consolidation, through the specific GPCR, GRPR-mediated mechanisms.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
Publication statusPublished - Jan 1 2015


  • bombesin
  • bombesin-like peptide
  • central nervous system
  • gastrin-releasing peptide (GRP)
  • gastrin-releasing peptide receptor (GRPR)
  • gastrointestinal tract

ASJC Scopus subject areas

  • Medicine(all)


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