Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer

Lisheng Chen; Nagahide Matsubara; Tadashi Yoshino; Takeshi Nagasaka; Naoko Hoshizima; Yasuhiro Shirakawa; Yoshio Naomoto; Hiroshi Isozaki; Karl Riabowol; Noriaki Tanaka

Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer

Lisheng Chen, Nagahide Matsubara, Tadashi Yoshino, Takeshi Nagasaka, Naoko Hoshizima, Yasuhiro Shirakawa, Yoshio Naomoto, Hiroshi Isozaki, Karl Riabowol, Noriaki Tanaka

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Overexpression of ING1, a candidate tumor suppressor gene, efficiently blocks cell growth or induces apoptosis in different experimental systems. ING1 maps to chromosome 13q33-34, and because loss of the terminal region of chromosome 13q has been implicated in esophageal squamous cell cancer (ESCC), we examined ESCC for genetic alterations of ING1. Among 31 informative cases of ESCC, 58.9% of the tumors showed allelic loss at chromosome 13q33-34, and we detected four tumor-specific missense nucleotide changes. These alterations were found within the PHD finger domain and nuclear localization motif of the ING1 and may be functionally involved in the development of ESCC. Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.

Original language	English
Pages (from-to)	4345-4349
Number of pages	5
Journal	Cancer Research
Volume	61
Issue number	11
Publication status	Published - Jun 1 2001

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{592f35ec2d7d49ebbba8f5f190d8db8c,

title = "Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer",

abstract = "Overexpression of ING1, a candidate tumor suppressor gene, efficiently blocks cell growth or induces apoptosis in different experimental systems. ING1 maps to chromosome 13q33-34, and because loss of the terminal region of chromosome 13q has been implicated in esophageal squamous cell cancer (ESCC), we examined ESCC for genetic alterations of ING1. Among 31 informative cases of ESCC, 58.9% of the tumors showed allelic loss at chromosome 13q33-34, and we detected four tumor-specific missense nucleotide changes. These alterations were found within the PHD finger domain and nuclear localization motif of the ING1 and may be functionally involved in the development of ESCC. Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.",

author = "Lisheng Chen and Nagahide Matsubara and Tadashi Yoshino and Takeshi Nagasaka and Naoko Hoshizima and Yasuhiro Shirakawa and Yoshio Naomoto and Hiroshi Isozaki and Karl Riabowol and Noriaki Tanaka",

year = "2001",

month = jun,

day = "1",

language = "English",

volume = "61",

pages = "4345--4349",

journal = "Cancer Research",

issn = "0008-5472",

number = "11",

}

TY - JOUR

T1 - Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer

AU - Chen, Lisheng

AU - Matsubara, Nagahide

AU - Yoshino, Tadashi

AU - Nagasaka, Takeshi

AU - Hoshizima, Naoko

AU - Shirakawa, Yasuhiro

AU - Naomoto, Yoshio

AU - Isozaki, Hiroshi

AU - Riabowol, Karl

AU - Tanaka, Noriaki

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Overexpression of ING1, a candidate tumor suppressor gene, efficiently blocks cell growth or induces apoptosis in different experimental systems. ING1 maps to chromosome 13q33-34, and because loss of the terminal region of chromosome 13q has been implicated in esophageal squamous cell cancer (ESCC), we examined ESCC for genetic alterations of ING1. Among 31 informative cases of ESCC, 58.9% of the tumors showed allelic loss at chromosome 13q33-34, and we detected four tumor-specific missense nucleotide changes. These alterations were found within the PHD finger domain and nuclear localization motif of the ING1 and may be functionally involved in the development of ESCC. Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.

AB - Overexpression of ING1, a candidate tumor suppressor gene, efficiently blocks cell growth or induces apoptosis in different experimental systems. ING1 maps to chromosome 13q33-34, and because loss of the terminal region of chromosome 13q has been implicated in esophageal squamous cell cancer (ESCC), we examined ESCC for genetic alterations of ING1. Among 31 informative cases of ESCC, 58.9% of the tumors showed allelic loss at chromosome 13q33-34, and we detected four tumor-specific missense nucleotide changes. These alterations were found within the PHD finger domain and nuclear localization motif of the ING1 and may be functionally involved in the development of ESCC. Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0035361341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035361341&partnerID=8YFLogxK

M3 - Article

C2 - 11389058

AN - SCOPUS:0035361341

SN - 0008-5472

VL - 61

SP - 4345

EP - 4349

JO - Cancer Research

JF - Cancer Research

IS - 11

ER -

Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer

Abstract

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this