Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10

Jumpei Uchiyama, Mohammad Rashel, Iyo Takemura, Shin ichiro Kato, Takako Ujihara, Asako Muraoka, Shigenobu Matsuzaki, Masanori Daibata

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Bacteriophage (phage) KPP10 has been used in experimental phage therapies directed against P. aeruginosa infections. To examine the eligibility of phage KPP10 as a therapeutic phage, its genome was analyzed. The genomic DNA was shown to be 88,322 bp long, with 158 open reading frames (ORFs), and three tRNA genes were predicted. No ORF-encoded pathogenicity or lysogenization factor was predicted. A comparative genomic analysis revealed that phage KPP10, together with phage PAK_P3, can be grouped as a new type of lytic phage infecting P. aeruginosa. Phage KPP10 is considered to be suitable for therapeutic purposes because it is a lytic phage without ORF-encoded pathogenicity or a lysogenization factors.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalArchives of Virology
Issue number4
Publication statusPublished - Apr 2012
Externally publishedYes


  • Bacteriophage
  • Genomes
  • Pseudomonas aeruginosa
  • Therapeutic phage

ASJC Scopus subject areas

  • Virology


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