Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

Nobushige Tsuboi; Joji Ishida; Yosuke Shimazu; Hisanori Edaki; Atsuhito Uneda; Yoshihiro Otani; Kentaro Fujii; Kazuhiko Kurozumi; Daisuke Ennishi; Hiroyuki Yanai; Isao Date

doi:10.18926/AMO/63907

Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

Nobushige Tsuboi, Joji Ishida, Yosuke Shimazu, Hisanori Edaki, Atsuhito Uneda, Yoshihiro Otani, Kentaro Fujii, Kazuhiko Kurozumi, Daisuke Ennishi, Hiroyuki Yanai, Isao Date

University Hospital

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.

Original language	English
Pages (from-to)	473-477
Number of pages	5
Journal	Acta medica Okayama
Volume	76
Issue number	4
DOIs	https://doi.org/10.18926/AMO/63907
Publication status	Published - 2022

Keywords

Genomic profiling
Glioneuronal tumor with neuropil-like islands

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.18926/AMO/63907

Cite this

@article{4a3dc04963644d468b6e9c1496c21e6d,

title = "Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands",

abstract = "Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.",

keywords = "Genomic profiling, Glioneuronal tumor with neuropil-like islands",

author = "Nobushige Tsuboi and Joji Ishida and Yosuke Shimazu and Hisanori Edaki and Atsuhito Uneda and Yoshihiro Otani and Kentaro Fujii and Kazuhiko Kurozumi and Daisuke Ennishi and Hiroyuki Yanai and Isao Date",

note = "Funding Information: We thank Masako Arao and Yukie Ukai for their technical assistance. We thank Chris Rowthorn, from Chris Rowthorn Japan, for editing a draft of this manuscript. Publisher Copyright: {\textcopyright} 2022 by Okayama University Medical School",

year = "2022",

doi = "10.18926/AMO/63907",

language = "English",

volume = "76",

pages = "473--477",

journal = "Acta Medica Okayama",

issn = "0386-300X",

publisher = "Okayama University",

number = "4",

}

TY - JOUR

T1 - Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

AU - Tsuboi, Nobushige

AU - Ishida, Joji

AU - Shimazu, Yosuke

AU - Edaki, Hisanori

AU - Uneda, Atsuhito

AU - Otani, Yoshihiro

AU - Fujii, Kentaro

AU - Kurozumi, Kazuhiko

AU - Ennishi, Daisuke

AU - Yanai, Hiroyuki

AU - Date, Isao

N1 - Funding Information: We thank Masako Arao and Yukie Ukai for their technical assistance. We thank Chris Rowthorn, from Chris Rowthorn Japan, for editing a draft of this manuscript. Publisher Copyright: © 2022 by Okayama University Medical School

PY - 2022

Y1 - 2022

N2 - Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.

AB - Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.

KW - Genomic profiling

KW - Glioneuronal tumor with neuropil-like islands

UR - http://www.scopus.com/inward/record.url?scp=85138139886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85138139886&partnerID=8YFLogxK

U2 - 10.18926/AMO/63907

DO - 10.18926/AMO/63907

M3 - Article

C2 - 36123163

AN - SCOPUS:85138139886

SN - 0386-300X

VL - 76

SP - 473

EP - 477

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 4

ER -

Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this